Protein

UniProt accession
P0DTN7 [UniProt]
Protein name
Depolymerase, capsule K2-specific
RBP type
TSP
Evidence DepoCatalog
Probability 1,00
Protein sequence
MALYREGKAAMAADGTVTGTGTKWQSSLSLIRPGATIMFLSSPIQMAVVNKVVSDTEIKAITTNGAVVASTDYAILLSDSLTVDGLAQDVAETLRYYQSQETVIADAVEFFKEFDFESLQNLANQIKADSEASESSAAAAAASESKAKTSEDNAKSSENAAKNSEVAAETTRDQIQQIIDNAGDQSTLVVLAQPDGFDSIGRVSSFAALRNLKPKKSGQHVLLTSYYDGWAAENKMPTGGGEFISSIGTATDDGGYIAAGPGYYWTRVVNNNSFTAEDFGCKTTATPPPNFNVLPAELFDNTAMMQAAFNLAISKSFKLNLSTGTYYFESSDTLRITGPIHIEGRPGTVFYHNPSNKANPKTDAFMNISGCSMGRISSINCFSNSYLGKGINFDRSVGDNRKLVLEHVYVDTFRWGFYVGEPECINQIEFHSCRAQSNYFQGIFIESFKEGQQYGHSAPVHFFNTICNGNGPTSFALGATYKTTKNEYIKVMDSVNDVGCQAYFQGLSNVQYIGGQLSGHGSPRNTSLATITQCNSFIIYGTDLEDINGFTTDGTAITTDNIDTIESNYLKDISGAAIVVSSCLGFKIDSPHIFKINTLSTIKLMNNTYNYEIGGFTPDEALKYNVWDANGLATNRISGVIHPRLVNSQLGINSVAFDNMSNKLDVSSLIHNETSQIIGLIPSTGSNVPHTRIMWSNGAMYSSTDLNNGFRLNYLSNHNEPLTPMHLYNEFSVSEFGGSVTESNALDEIKYIFIQTTYANSGDGRFIIQALDASGSVLSSNWYSPQSFNSTFPISGFVRFDVPTGAKKIRYGFVNSANYTGSLRSHFMSGFAYNKRFFLKIYAVYNDLGRYGQFEPPYSVAIDRFRVGDNTTQMPSIPASSATDVAGVNEVINSLLASLKANGFMSS
Physico‐chemical
properties
protein length:907 AA
molecular weight: 98566,60600 Da
isoelectric point:5,19397
aromaticity:0,10805
hydropathy:-0,20849

Domains

Domains [InterPro]
G3DSA:6.10.140.1630
871–907
G3DSA:6.10.140.1630
P0DTN7
1 907
Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Taxonomy

  Name Taxonomy ID Lineage
Phage Klebsiella phage B1
[NCBI] 		2823852 Viruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)

No CDS data available.

Gene Ontology

Description Category Evidence (source)
GO:0098024 virus tail, fiber Cellular Component IEA:UniProtKB-KW (UniProt)
GO:0098671 adhesion receptor-mediated virion attachment to host cell Biological Process IEA:UniProtKB-KW (UniProt)
GO:0098994 symbiont entry into host cell via disruption of host cell envelope Biological Process IEA:UniProtKB-KW (UniProt)
GO:0098996 symbiont entry into host cell via disruption of host cell glycocalyx Biological Process IDA:UniProtKB (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
ed38c58418078760c8c48dc1dd74698c14facb08bdd7fd870ce50a566c5c7b58
AlphaFold3
Source AlphaFold3
Method AlphaFold3
Resolution 0,8689
Evidence 0,8689
Download PDB
PDB ID
ed38c58418078760c8c48dc1dd74698c14facb08bdd7fd870ce50a566c5c7b58
ESMFold
Source ESMFold
Method ESMFold
Resolution 0,6357
Evidence 0,6357
Download PDB

Literature

Title Authors Date PMID Source
Isolation and Characterization of a Novel Lytic Bacteriophage against the K2 Capsule-Expressing Hypervirulent Klebsiella pneumoniae Strain 52145, and Identification of Its Functional Depolymerase. Pertics BZ, Cox A, Nyúl A, Szamek N, Kovács T, Schneider G 2021-03-21 33801047 PubMed
Isolation and Characterization of a Novel Lytic Bacteriophage against the K2 Capsule-Expressing Hypervirulent Klebsiella pneumoniae Strain 52145, and Identification of Its Functional Depolymerase Botond Zsombor Pertics, Alysia Cox, Adrienn Nyúl, Nóra Szamek, Tamás Kovács, György Schneider 2021-03-21 10.3390/microorganisms9030650 DOI