Protein

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UniProt accession
A0AAE7MU86 [UniProt]
Protein name
Endo-N-acetylneuraminidase
RBP type
TF
Evidence Phold
Probability 1,00
TSP
Evidence DepoScope
Probability 1,00
TSP
Evidence RBPdetect
Probability 0,90
TSP
Evidence RBPdetect2
Probability 0,54
Protein sequence
MSTITQFPSGNTQYRIEFDYLSRTFVVVTLVNSSNPTLNRVLEVGRDYRFLNPTMIEMLVDQSGFDIVRIHRQTGTDLVVDFRNGSVLTASDLTNSELQAIHIAEEGRDQTVDLVKEYADAAGSSAGNAKDSEDEARRIADNIQASGRIGYITRRSFEKGINITTWNEVLLWEADGEYYRWDGGLPKTVPVGSTPETSGGVGLGAWVSVGDASLRADIAKPTGTNLIGTKNGETLSTVLSSRWANSGADKKEISFDLPLLFPDYDAILAAHPDWTFIYPGSFCIGDDGNIYIAYGPSNNAATERFVVVYSGEGEYLGYLQTNNGGTGVNGSAVSEGIIVTNYYGSLKLFLGSYDGNLAEFDISAVTYGTTISYTALHQVGLYNQFSFHNGMWAVEQAIPALGINRQRNVIAYFNSAFALTGFTEFSPYDAGYITTTTTDYGPLQTKRQAICLAPGVLIMAFGGVYITGTTVEAPTNYQGVKAFSTDGHKMVEAVMPPTGFISVLDAKGLTTSRIENEGICYSNGEVFTLWIYNNRTASNAYTHGILITKEYSNSPDLDFSAVTTVSPGYDTIRMASGVYPRILAGDVLYNPLTGSAMTSMSAVLDFMRLSGQKAVTIYTSSTGLTDLDGVAYPIGIELHISNLNNQSFSIDQTGPTTRKTVRVTYDTSGYTVITGAIGLETYRLTLNNTDSGALTQGRIAARAFGNKTLTESEQILVLDQQSSASAHSLILGGGSSVFKSATSISFATNPSPETVGGTIRWRIDNTSLRPYTDNAYNLGNPALRVAQVFAAIGTINTSDSREKTYPFEISDDILDAWGDVQIITYKWLSSIAAKGEDSARWHFGVIAQQVRDTFIKHGLDGTTFGLLCYDEWEDEYEPEFVDEVITVNIDGVDTEVTRQVETGNTLLTRAAGNRWGIRPDQCFWLEAAYQRRRCDRIETRLDKLEGCGGRG
Physico‐chemical
properties
protein length:951 AA
molecular weight: 103610,14230 Da
isoelectric point:4,75625
aromaticity:0,10200
hydropathy:-0,18065

Domains

Domains [InterPro]
DC_0539
STR
2–56
DC_0539 G3DSA:2.10.10.80 IPR044914 G3DSA:1.20.5.1240 G3DSA:1.20.5.100
IPR005604
ATT
10–117
IPR005604 IPR040775 IPR030392
DC_0539
STR
46–189
DC_0539 IPR030392
DC_0539
STR
165–817
DC_0539
cd10144
CHP
798–933
cd10144
A0AAE7MU86
1 951
Architecture
ATT
STR
ATT
STR
RBD
CHP
RBD
ATT 2-117 | STR 118-149 | ATT 150-220 | STR 221-817 | RBD 818-861 | CHP 862-917 | RBD 918-947 |
Legend: ATT STR RBD CBM LEC ENZ CHP LNK TAS TTP UNK Unmapped

Tail Spike Domain Segmentation

Tail Spike Domain Segmentation

This protein has been segmented into three structural domains: N-terminal, central domain, and C-terminal.

Domain Layout
N-terminal
Central
C-terminal
A0AAE7MU86
1 951
Domain Start End Length (AA) Confidence
N-terminal 1 245 245 0,9971
Central domain 246 511 267 0,9832
C-terminal 512 951 439 0,6127
Legend: N-terminal Central domain C-terminal
3D Structure with Domain Coloring

The structure is colored according to the domain segmentation: N-terminal (blue), Central (green), C-terminal (pink).

Domain Coloring
N-terminal
1-245
Central
246-511
C-terminal
512-951

Taxonomy

  Name Taxonomy ID Lineage
Phage Escherichia phage vB_EcoP-U8
[NCBI] 		2775261 Viruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes
Host Escherichia coli
[NCBI] 		562 cellular organisms > Bacteria > Pseudomonadati > Pseudomonadota > Gammaproteobacteria > Enterobacterales

Coding sequence (CDS)

Coding sequence (CDS)

No CDS data available.

Genome Context

Genome Context

Gene Ontology

Description Category Evidence (source)
GO:0098015 virus tail Cellular Component IEA:UniProtKB-KW (UniProt)
GO:0016996 endo-alpha-(2,8)-sialidase activity Molecular Function IEA:UniProtKB-EC (UniProt)
GO:0098671 adhesion receptor-mediated virion attachment to host cell Biological Process IEA:UniProtKB-KW (UniProt)
GO:0046718 symbiont entry into host cell Biological Process IEA:UniProtKB-KW (UniProt)

Tertiary structure

PDB ID
7966384acb185535fc8a2ee8ae288c27d8c283d8158e701ef1717f454cd7d548
ColabFold
Source ColabFold
Method ColabFold
Resolution 0,2974
Oligomeric State monomer
Download PDB
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50