Protein

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Genbank accession

AXY86125.1 [GenBank]

Protein name

tail spike protein

RBP type

Evidence Phold

Probability 1,00

TSP

Evidence DepoScope

Probability 1,00

TSP

Evidence RBPdetect

Probability 0,91

TSP

Evidence RBPdetect2

Probability 0,94

Protein sequence

MSYNPIVEGSTWPETIRRLEKTDRAEGGQLVTNSKDEPVSGHINHPITQLATRTSILKKSNLSIINNTKEQWKLLLGDLGLTLVGTFEEGATVNSKKDAVWHIDGGQCYVWGGVLPKTVYANSSPLTTGGVSSDAWVSIGDTALRGQISDPDGATKYPELQIARWRDIFDPRGWGAKGDGLVDDTVALNNLLSAAPVGQKINGNGRTYKVSALPDISRFVNTRFVYERIPGQPLYYVSDEFVQGELIKITDTPYYNAWPQDKAFVYDDVIYCPFMASDRHGVSRLHVSWVRSGDDGQTWTTPEWLTDLHPNYPTVNYHCMSMGVMRNRLFAMIETRTLAANALVTCELWDRPMSRNYHLTGGITKAANQPVAVITIPEHGLFAGDFVNFSNSGVTGVSGNMTVTSVIDRNTFTVTTPNQQAFDQNNSTSRWHMGTSFHQSPWRKTSLGLIPMVTEVHSFTAINNDSFMMGYHQGDVAPREVGMLYFPDAFNNPGHYIKRRIPAEYEPDAAEPCVKYFDGVLYVVTRGTRSDRLGSSLHRSNDLGITWQSLRFPNNVHHSTLPFAKVGNELILFGTERADNEWEANAPDQRYFSSYPRTFYTRVNLDTWNLDNTQWVNITDQIYQGGIVNSGVGVGSVVVKDSYIYYMFGGEDHLNPWTYGDNLEKDPFKSDGHPSDLYCYKMQIGPDNRVSRDFRYGAVPDRAVPVFFDTNGVRTVPAPMEFTGDLGLGHVTIRASTSSNIRSEVLMEGEYGFIGKSVPTNNPAGQRIIFCGGDGTSSSTGAQITLYGASNTASRRIVYNGDEHLFRSADVKPYNDNVIALGGPSNRFTTAYLGSNPIVTSNGEKKTEPVVFDDAFLDAWGDVHYIMYQWLDSVHLKGNDARIHFGVIAQQIRDVFIAHGLMDENSTDCRYAVLCYDKYPRMTDMVFSHYEIVEHTDEEGNVTTTEEPVYTEVVIHEEGEEWGVRPDGIFFAEAAFQRRRLERIEARLSDLEKKQ

Physico‐chemical properties

protein length:	995 AA
molecular weight:	111331,97890 Da
isoelectric point:	5,40535
aromaticity:	0,10854
hydropathy:	-0,41417

Domains

Domains [InterPro]

DC_1348
ATT
2–281

DC_1348 IPR001724 IPR024427 IPR001724 IPR001724 IPR001724 IPR044914 cd10144

G3DSA:2.10.10.80
ATT
81–150

G3DSA:2.10.10.80 G3DSA:3.30.750.60 IPR024428 IPR024430 IPR030392

IPR040775
RBD
85–141

IPR040775 IPR036278 SSF69349 IPR030392 G3DSA:3.30.2460.10 G3DSA:1.20.5.100

IPR024429
ENZ
176–242

IPR024429 G3DSA:2.120.10.10 IPR001724 IPR001724 G3DSA:1.20.5.1240 Coil

IPR001724
Unmapped
244–268

IPR001724 IPR023366

IPR001724
Unmapped
428–451

IPR001724

AXY86125.1

1 995

Architecture

ATT

STR

CHP

RBD

CHP

RBD

ATT 2-281 | STR 282-840 | CHP 841-853 | RBD 854-905 | CHP 906-964 | RBD 965-994 |

Legend: ATT STR RBD CBM LEC ENZ CHP LNK TAS TTP UNK Unmapped

Domains [InterPro]

Domain ID	Category	Cluster	Start	End	Layer	Name	Pref Zone	Confidence	Evidence	Support
DC_1348	ATT	DC_1348	2	281	Novel HMM	DC_1348	N-terminal	Low	Positional only	38 proteins / 38 hits
G3DSA:2.10.10.80	ATT	G3DSA:2.10.10.80	81	150	Merged direct domain	G3DSA:2.10.10.80	N-terminal	Low	Positional only	383 proteins / 383 hits
IPR040775	RBD	DC_0821	85	141	InterPro cluster	Tail spike TSP1/Gp66, N-terminal domain	Central	High	Text match	1281 proteins / 1285 hits
G3DSA:3.30.750.60	ATT	G3DSA:3.30.750.60	170	242	Merged direct domain	G3DSA:3.30.750.60	N-terminal	Low	Positional only	2 proteins / 2 hits
IPR036278	STR	IPR036278	175	690	Merged direct domain	Sialidase superfamily	Central	Low	Positional only	56 proteins / 56 hits
IPR024429	ENZ	DC_0802	176	242	InterPro cluster	Endosialidase, N-terminal extension domain	N-terminal	High	Text match	84 proteins / 84 hits
IPR024428	ENZ	DC_0114	243	684	InterPro cluster	Endosialidase, beta-propeller domain	Central	High	Text match	92 proteins / 92 hits
G3DSA:2.120.10.10	STR	G3DSA:2.120.10.10	244	684	Merged direct domain	G3DSA:2.120.10.10	Central	Low	Positional only	42 proteins / 42 hits
IPR001724	Unmapped	-	244	268	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	309	337	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR024427	ENZ	DC_0382	354	436	InterPro cluster	Endosialidase, beta-barrel domain	Central	High	Text match	86 proteins / 86 hits
IPR023366	STR	IPR023366	354	440	Merged direct domain	ATP synthase subunit alpha, N-terminal domain-like superfamily	Central	Low	Positional only	44 proteins / 44 hits
IPR001724	Unmapped	-	428	451	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	498	524	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	576	602	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	632	656	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR044914	RBD	IPR044914	687	840	Merged direct domain	Endosialidase, C-terminal domain superfamily	C-terminal	Low	Positional only	39 proteins / 39 hits
IPR024430	ENZ	DC_0521	687	840	InterPro cluster	Endosialidase, C-terminal domain	C-terminal	High	Text match	95 proteins / 95 hits
SSF69349	STR	SSF69349	691	840	Merged direct domain	SSF69349	Central	Low	Positional only	153 proteins / 153 hits
IPR001724	Unmapped	-	733	759	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	765	792	InterPro	Glycosyl hydrolase 58	-	-	-	-
cd10144	CHP	DC_0088	841	980	InterPro cluster	cd10144	C-terminal	High	Text match	3502 proteins / 3959 hits
IPR030392	CHP	DC_0088	841	991	InterPro cluster	Intramolecular chaperone auto-processing domain	C-terminal	High	Text match	3502 proteins / 3959 hits
IPR030392	CHP	DC_0088	845	901	InterPro cluster	Intramolecular chaperone auto-processing domain	C-terminal	High	Text match	3502 proteins / 3959 hits
G3DSA:1.20.5.1240	RBD	G3DSA:1.20.5.1240	854	905	Merged direct domain	G3DSA:1.20.5.1240	C-terminal	Low	Positional only	1 proteins / 1 hits
G3DSA:3.30.2460.10	Unmapped	-	906	964	Gene3D	None	-	-	-	-
G3DSA:1.20.5.100	RBD	G3DSA:1.20.5.100	965	994	Merged direct domain	G3DSA:1.20.5.100	C-terminal	Low	Positional only	8 proteins / 8 hits
Coil	Unmapped	-	974	994	Coils	Coil	-	-	-	-

Tail Spike Domain Segmentation

This protein has been segmented into three structural domains: N-terminal, central domain, and C-terminal.

Domain Layout

N-terminal

Central

C-terminal

AXY86125.1

1 995

Domain	Start	End	Length (AA)	Confidence
N-terminal	1	199	199	0,9429
Central domain	200	507	309	0,8486
C-terminal	508	995	487	0,6340

Legend: N-terminal Central domain C-terminal

3D Structure with Domain Coloring

The structure is colored according to the domain segmentation: N-terminal (blue), Central (green), C-terminal (pink).

Domain Coloring

N-terminal
1-199

Central
200-507

C-terminal
508-995

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Escherichia phage vB_EcoM_IME392 [NCBI]	2301649	No lineage information
Host	Escherichia coli [NCBI]	562	cellular organisms > Bacteria > Pseudomonadati > Pseudomonadota > Gammaproteobacteria > Enterobacterales

Coding sequence (CDS)

Genbank protein accession

AXY86125.1 [NCBI]

Genbank nucleotide accession

MH719082.1 [NCBI]

CDS location

range 91505 -> 94492
strand +

CDS

ATGTCTTATAATCCAATTGTAGAAGGGTCAACTTGGCCCGAGACTATTCGCCGCTTAGAAAAGACGGATAGGGCAGAAGGCGGTCAACTAGTTACTAATTCTAAGGATGAACCAGTATCCGGACATATTAATCATCCAATAACCCAATTAGCTACTAGAACCTCCATTTTAAAAAAGTCTAATTTATCGATAATTAATAATACTAAAGAACAGTGGAAGTTATTACTCGGTGACTTAGGACTAACTCTTGTTGGCACTTTTGAAGAAGGTGCTACAGTAAACAGTAAAAAGGATGCTGTCTGGCATATTGATGGTGGCCAGTGCTACGTGTGGGGTGGCGTGCTCCCTAAGACTGTATATGCTAACTCCTCACCGCTAACTACTGGTGGTGTCTCTTCTGATGCTTGGGTTAGTATTGGTGATACCGCACTGCGAGGGCAAATATCAGACCCGGATGGTGCAACAAAATACCCCGAATTGCAGATTGCTCGATGGCGTGACATTTTCGACCCTCGTGGTTGGGGAGCTAAAGGTGATGGATTAGTCGATGATACTGTGGCTCTTAATAATCTGTTAAGCGCTGCTCCAGTAGGTCAGAAAATTAATGGTAACGGCAGAACCTATAAAGTATCCGCACTTCCAGATATTAGCAGATTCGTTAACACTCGTTTCGTTTATGAGCGTATTCCTGGCCAGCCGCTTTATTATGTATCTGACGAGTTTGTTCAGGGTGAGTTAATTAAAATAACCGATACCCCTTATTACAATGCTTGGCCTCAGGATAAAGCGTTCGTTTACGACGATGTTATTTACTGTCCGTTCATGGCTAGCGATCGGCACGGGGTTAGCAGGCTTCATGTATCCTGGGTTCGCTCAGGTGATGACGGACAGACCTGGACGACCCCGGAGTGGCTAACTGACCTACACCCTAATTACCCAACAGTTAACTACCACTGTATGAGTATGGGGGTGATGCGTAATCGTCTCTTTGCGATGATTGAGACCCGTACTTTAGCAGCTAACGCATTAGTGACCTGTGAGTTGTGGGATCGCCCCATGTCCCGTAACTACCATCTGACAGGTGGTATAACAAAAGCTGCCAACCAGCCTGTGGCTGTAATTACCATCCCTGAACACGGTCTTTTTGCTGGGGATTTTGTTAACTTCTCGAACTCTGGGGTGACTGGCGTTTCTGGGAATATGACTGTAACTTCAGTTATTGACCGCAACACGTTTACAGTTACCACGCCAAATCAACAAGCATTCGACCAAAATAACTCTACCAGCCGCTGGCATATGGGGACATCGTTCCATCAGTCACCATGGCGTAAAACCAGCCTTGGATTGATCCCTATGGTTACCGAGGTTCACAGTTTTACCGCCATCAATAACGATTCATTCATGATGGGGTACCATCAGGGTGATGTTGCTCCGCGTGAAGTAGGTATGTTGTATTTCCCTGATGCATTTAACAATCCTGGGCATTATATAAAACGACGTATCCCTGCTGAATATGAGCCGGATGCGGCAGAACCCTGTGTTAAATATTTTGACGGTGTTCTTTATGTTGTAACCCGTGGAACTCGGTCGGACCGTCTGGGTAGTTCGCTTCATCGTAGTAATGATTTGGGTATAACCTGGCAATCATTGAGGTTCCCGAATAATGTCCACCACTCCACCCTGCCATTCGCTAAGGTAGGAAACGAACTGATTCTTTTCGGCACTGAACGCGCCGACAACGAGTGGGAAGCAAACGCACCCGACCAGCGATATTTTAGTTCTTACCCACGAACGTTTTACACGCGAGTGAACCTCGACACCTGGAACCTGGATAATACTCAGTGGGTGAATATCACTGACCAGATTTATCAGGGTGGTATTGTTAACTCTGGCGTCGGTGTCGGATCGGTCGTCGTGAAAGATAGTTATATCTATTACATGTTCGGTGGGGAAGACCATCTGAACCCATGGACATATGGAGATAACTTAGAGAAAGACCCATTCAAATCAGACGGTCATCCCTCAGATTTGTATTGTTACAAAATGCAGATCGGTCCAGACAATCGTGTTTCTCGTGATTTCAGGTACGGTGCTGTACCTGACAGAGCGGTTCCAGTGTTTTTTGATACGAATGGAGTTCGCACTGTTCCTGCTCCAATGGAATTTACAGGGGATTTGGGTTTAGGTCATGTGACCATTAGAGCCAGCACCAGTAGTAACATTCGCTCTGAAGTTTTAATGGAAGGTGAGTATGGGTTTATCGGGAAATCTGTACCGACTAATAACCCTGCAGGTCAGCGCATCATATTTTGCGGAGGCGACGGTACCAGTTCTTCTACTGGTGCACAGATTACGCTTTACGGTGCGAGTAACACAGCTTCTCGCAGGATAGTTTACAACGGAGATGAGCATCTGTTTCGGAGTGCTGATGTTAAGCCTTATAACGATAACGTCATTGCGCTTGGTGGGCCTAGCAACCGTTTCACCACTGCATACCTCGGAAGCAACCCTATTGTTACTTCTAACGGAGAGAAGAAAACAGAGCCGGTAGTTTTTGATGATGCTTTTTTAGATGCTTGGGGCGATGTTCATTACATCATGTATCAGTGGTTGGATTCTGTACACCTGAAAGGAAATGACGCTAGAATCCATTTTGGCGTAATTGCTCAGCAGATCCGCGATGTATTCATTGCTCACGGTCTGATGGATGAGAACAGCACGGATTGCCGCTATGCTGTTCTGTGTTACGACAAATATCCTCGCATGACAGACATGGTGTTCTCTCACTATGAAATAGTTGAACACACTGACGAGGAGGGTAATGTCACTACCACGGAAGAACCTGTATACACCGAGGTGGTTATTCACGAAGAGGGTGAGGAGTGGGGTGTGAGGCCTGATGGAATTTTCTTTGCTGAGGCAGCATTCCAGAGAAGAAGACTGGAAAGAATCGAAGCCAGACTTTCCGATCTTGAAAAGAAGCAGTAA

Genome Context

Tertiary structure

PDB ID

1e5b16dc4acb2f887cc17411d816e029aeda4df1bbb3fbac4e27ad54a0de4204

ESMFold

Source ESMFold

Method ESMFold

Resolution 0,6638

Oligomeric State monomer

Download PDB

Model Confidence

Very high
pLDDT > 90

High
90 > pLDDT > 70

Low
70 > pLDDT > 50

Very low
pLDDT < 50

Protein

Domains

Domains [InterPro]

Domains [InterPro]

Tail Spike Domain Segmentation

Tail Spike Domain Segmentation

3D Structure with Domain Coloring

Domain Coloring

Taxonomy

Coding sequence (CDS)

Coding sequence (CDS)

Genome Context

Genome Context

Tertiary structure

Predicted Aligned Error (PAE)

Model Confidence