Protein

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UniProt accession

A0A9E7SQM2 [UniProt]

Protein name

receptor protein-tyrosine kinase

RBP type

TSP

Evidence DepoScope

Probability 1,00

Protein sequence

MTDYTSILHLPQVGSNQEQKEATINTAIAILEASANDTLVLSLASGDVTLNTDQFTKYFLHQFTGHAVARQVTIPATPRWFAVENRGAAPIVFKVMGASGLTAELPANRIGLVVADGTNVRFVVPDPISGMGLLRDLSDVDGLPVDGQLLRYDATAAQWKPWTWTAAFTQLSDTPSSLGGNAGKLVAVNAAGNRLEFITSAANINSFIDLDDTPTSYASAANRHVVVNAAGTGLTFARPYLRENSDFPSSYNTHANKMLRVNATADGVIFSNPVVGDLTDGPGAPTINEALLYVRVNAAGTALEYVTGTGGPVNFTELHDTPSNFTGHKGKLVRVGQDEDRLIFSELKLTELSDTPNSFTGAANKILKVNATQSGVIFGSLKVEELADGPGPMAAAQRGLYLRVNATNSGLEYVKPALTELAGVPSFTGQGGKFVRVNDAENGLDFAVNAVDMAFIGLSDTPANYQNSQNKFVAVNAQGTGLIFVPAPTGGGGGGGPYSLDQITDVDAPDPSAGQVLTFRDGWWRPETPSGGGGVGATALSELTDVNFTLKVPEENDVLTFQGGFWVAKPANATPIPQALDDLTDVDLSEGTLANGEVLTYWDGKWIHAPVQVPSGDGLRFGEHRDWRLFFRTADTPALEIAEFVLRAGAGLPQLAVGGTPSANANAGAAFDADKAFDGDPATFWRTGADGADQSWLRYTFAEPQEVNAVSLTFGAVRQLPITWAMQFSDDGGLTWITAWSETRAFGWNAGETVDTEPARAKLAFAMLSDSPGAMSAHPGKFVRVDEDGVRLEYVELPIPATSLEELTDVQFTAPPAEDQVLTFKDGIWQPKDPASTVTPEMALNDLTDVDTAGQADGMILGRRGGVWRPLDGVHDLGQHAYWRILVQDTGAYPGTTTVIVAEVSLRDAPGGAQTATGGAAIGTGGNINGAFDGTSGDVWTAYLPDAWIGYHYAAPIALQEVALTASTVTGWAPNYTPEAFKVQYSDDGLAWFDGWEVAGSTGWVEGETRVYTQPGRLQLFTDLDDTPNTYATHGGKQVRVRTDATGLEFVTPPTIPNALDDLTDVDLTTTAPATGNLLTFEGGKWIAKVPAPVSYTDLQDKPTIPVNLADLGDVSDTPATAGDYLRFVGGEWVADATPAAGATRMGELSDVDETGVAAGDVLIYHSPVGDPAEWRPGKLALDALSDVAAAAPVNGQALVFRDGSWTPEDVAGAGLDPDRQQVALLIVNPGAEDGMTGWTNTAGAFTSETSAGSLGAPFAGTRIFRATQNTSPCEMAQTIALDAALWDYIDIGRGSVEVAFRYGRVNTDGSTALVALEALDAVGTLITSSASPAYTTTTTWQLGNVSHVLPPLTRSVRLVVRSTRTGTFNYGAFDAFSGLIKVASAHPALSDLPDVGPWTSVPVAGQVLTYRGGVWMNETPSAGNLDALTDVTLTTPVAGQILVYRAGQWINESPQGAGVPSNGSHAHWRLLIDQTDGDANQVGIQDIWFRQTKTGPQLATGGTPSASSSTSGQGPEGAFDGVTGGAWFSAAGNPVGQWIAYAFPAPVEVRYLDLKGSQDYPTRSPRAFKVQWSDDGSTWTTAWTVTGQTGWAPNQTRQFHAPLDLFFTDLADAPPSYIGQARKPIRVKADETGLEFGHDSLGDLTDVSFLTTPQEGEVLTRVSGQWRSVAPTTGSGNTSNWTAPWRGALVERTTDLTSVTWPTTVPWQAATADTDGFYTTGAATRLTIPAGITKVRISAHIAFTLTGNTGSVYGAIHRNGVAIKTGRSTARQNTLGFTNNEIYVTTRIVSVVPGDYFEIYANSNISGVNSILTSSWLQLEVIESDYAINPPEALDDLTDVTLGTPVQDYVLTYDGGVWKAKELPASSGGTVYMADIGDVEMPVGGPGENDVLRYQAGKWRPLPAGSADGLFLDNAMIGSGQGAPTTPRPSGSLYIDEVTGQISQSLKDVPTVAAAPTVVQHVLVDAYNALTSAQPITAALSTAPTEGNWLVALLCDQSLATAGAGWTLLPGSPVSSSTRVRPSVAYKQAAASETLSQTPFVSGSGQIIAGALVIYEIAGMSTWAEGYRGVVWEDDTTYTSSASGMARAPLTARALHDGLGLGLYVTRPNSSTLTADAPWTTLSSGVAPTGGGNRTYVATSAAAAAGTSIAPKASFTGATEAGYVTILLDNGPAAFEEGWRPYTGNIALDDLTDVTAPTPANGQVLTYRDGAWSPESAEGEFSGTGEPTATAPLGKVYQQRDSAGNAWVSTMVPAGATAPTPYAATGARQSFVVGPQISSLTFKLWGGGGGTGRYSTGGNPAAGGFTQATFAVNEGDLIELDVPSGGQGGFRSNYGGAGGWPDGGFGGLGDTACGGGGGSARVWRNGVLMAVAGGGGGGSGYTSTDAGAGGGSSGQSSSTTNGGTGGTQFAGGYDGNDTGSAPKRGGYLQGAQGTAAVDRFTSSSDDGGGGGGGYYGGGGGGGDGQPGGGGSGYLNLAAGVTGVTEAGDRLVPPRTTDADYQANIGVGYPTENVTGPAPNGGDGLIVVLAPPYVQGWRRLATSDDVDTLALVDLLKVTLQGDGDQDYVLTAQDRRAYRKITSSIDKTITIPPNSLVPFPIGASFSLQRGGDGRVSVLAGSGVSLEYPDDMQPRLRRKNSVASLVQIASNVWSLFGDLEPI

Physico‐chemical properties

protein length:	2660 AA
molecular weight:	276792,87640 Da
isoelectric point:	4,48388
aromaticity:	0,08459
hydropathy:	-0,14335

Domains

Domains [InterPro]

DC_0755
ATT
1–441

DC_0755 DC_1385 DC_1385 IPR000421 DC_0755 IPR000421 DC_1950 DC_0450

IPR000421
RBD
634–746

IPR000421 DC_1385 G3DSA:2.60.120.260 G3DSA:2.60.120.260 IPR055163

G3DSA:2.60.120.260
STR
657–785

G3DSA:2.60.120.260 IPR008979 DC_1385

IPR008979
STR
658–745

IPR008979 IPR008979

IPR000421
RBD
669–749

IPR000421 IPR000421

A0A9E7SQM2

1 2660

Architecture

ATT

RBD

STR

ATT 1-441 | ATT 447-539 | ATT 555-1121 | ATT 1136-1701 | RBD 1702-1824 | STR 2179-2596 |

Legend: ATT STR RBD CBM LEC ENZ CHP LNK TAS TTP UNK Unmapped

Domains [InterPro]

Domain ID	Category	Cluster	Start	End	Layer	Name	Pref Zone	Confidence	Evidence	Support
DC_0755	ATT	DC_0755	1	441	Novel HMM	DC_0755	N-terminal	Low	Positional only	28 proteins / 28 hits
DC_1385	ATT	DC_1385	447	539	Novel HMM	DC_1385	N-terminal	Low	Positional only	25 proteins / 25 hits
DC_1385	ATT	DC_1385	555	843	Novel HMM	DC_1385	N-terminal	Low	Positional only	25 proteins / 25 hits
IPR000421	RBD	DC_0058	634	746	InterPro cluster	Coagulation factor 5/8, C-terminal domain	C-terminal	Low	Positional only	33 proteins / 66 hits
G3DSA:2.60.120.260	STR	G3DSA:2.60.120.260	657	785	Merged direct domain	G3DSA:2.60.120.260	Central	Low	Positional only	264 proteins / 264 hits
IPR008979	STR	IPR008979	658	745	Merged direct domain	Galactose-binding-like domain superfamily	Central	Low	Positional only	24 proteins / 24 hits
IPR000421	RBD	DC_0058	669	749	InterPro cluster	Coagulation factor 5/8, C-terminal domain	C-terminal	Low	Positional only	33 proteins / 66 hits
DC_1385	ATT	DC_1385	836	1121	Novel HMM	DC_1385	N-terminal	Low	Positional only	25 proteins / 25 hits
IPR000421	RBD	DC_0058	899	992	InterPro cluster	Coagulation factor 5/8, C-terminal domain	C-terminal	Low	Positional only	33 proteins / 66 hits
IPR008979	STR	IPR008979	921	1011	Merged direct domain	Galactose-binding-like domain superfamily	Central	Low	Positional only	24 proteins / 24 hits
DC_0755	ATT	DC_0755	1136	1348	Novel HMM	DC_0755	N-terminal	Low	Positional only	28 proteins / 28 hits
G3DSA:2.60.120.260	STR	G3DSA:2.60.120.260	1225	1378	Merged direct domain	G3DSA:2.60.120.260	Central	Low	Positional only	264 proteins / 264 hits
DC_1385	ATT	DC_1385	1301	1701	Novel HMM	DC_1385	N-terminal	Low	Positional only	25 proteins / 25 hits
IPR000421	RBD	DC_0058	1483	1582	InterPro cluster	Coagulation factor 5/8, C-terminal domain	C-terminal	Low	Positional only	33 proteins / 66 hits
G3DSA:2.60.120.260	STR	G3DSA:2.60.120.260	1498	1607	Merged direct domain	G3DSA:2.60.120.260	Central	Low	Positional only	264 proteins / 264 hits
IPR008979	STR	IPR008979	1498	1593	Merged direct domain	Galactose-binding-like domain superfamily	Central	Low	Positional only	24 proteins / 24 hits
IPR000421	RBD	DC_0058	1506	1601	InterPro cluster	Coagulation factor 5/8, C-terminal domain	C-terminal	Low	Positional only	33 proteins / 66 hits
DC_1950	RBD	DC_1950	1676	1824	Novel HMM	DC_1950	C-terminal	Low	Positional only	17 proteins / 17 hits
DC_0450	STR	DC_0450	2179	2596	Novel HMM	DC_0450	Central	Low	Positional only	24 proteins / 24 hits
IPR055163	STR	DC_0678	2282	2476	InterPro cluster	ALK/LTK-like, glycine-rich domain	Central	Low	Positional only	4 proteins / 4 hits

Tail Spike Domain Segmentation

This protein has been segmented into three structural domains: N-terminal, central domain, and C-terminal.

Domain Layout

N-terminal

Central

C-terminal

A0A9E7SQM2

1 2660

Domain	Start	End	Length (AA)	Confidence
N-terminal	1	2283	2283	0,7186
Central domain	2284	2503	221	0,5353
C-terminal	2504	2660	156	0,1330

Note: Constraints were applied during segmentation.
Fixed 527 C-terminal predictions appearing before Central domain

Legend: N-terminal Central domain C-terminal

3D Structure with Domain Coloring

The structure is colored according to the domain segmentation: N-terminal (blue), Central (green), C-terminal (pink).

Domain Coloring

N-terminal
1-2283

Central
2284-2503

C-terminal
2504-2660

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Brevundimonas phage vB_BpoS-Gurke [NCBI]	2948599	Uroviricota > Caudoviricetes > Jeanschmidtviridae > Kikimoravirus gurke >
Host	Brevundimonas pondensis [NCBI]	2774189	cellular organisms > Bacteria > Pseudomonadati > Pseudomonadota > Alphaproteobacteria > Caulobacterales

Coding sequence (CDS)

No CDS data available.

Genome Context

Gene Ontology

	Description	Category	Evidence (source)
GO:0005886	plasma membrane	Cellular Component	IEA:UniProtKB-SubCell (UniProt)
GO:0005524	ATP binding	Molecular Function	IEA:UniProtKB-KW (UniProt)
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA:UniProtKB-EC (UniProt)

Tertiary structure

PDB ID

899528cbce5b1e837f155ce7dfc381fc5ad1449c164116a62819f3c3934d5084

ColabFold

Source ColabFold

Method ColabFold

Resolution 0,4504

Oligomeric State monomer

Download PDB

Model Confidence

Very high
pLDDT > 90

High
90 > pLDDT > 70

Low
70 > pLDDT > 50

Very low
pLDDT < 50

Protein

Domains

Domains [InterPro]

Domains [InterPro]

Tail Spike Domain Segmentation

Tail Spike Domain Segmentation

3D Structure with Domain Coloring

Domain Coloring

Taxonomy

Coding sequence (CDS)

Coding sequence (CDS)

Genome Context

Genome Context

Gene Ontology

Tertiary structure

Predicted Aligned Error (PAE)

Model Confidence