Protein

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Genbank accession

WPH64569.1 [GenBank]

Protein name

tail spike protein

RBP type

TSP

Evidence UniProt/TrEMBL

Probability 1,00

Evidence GenBank

Probability 1,00

TSP

Evidence DepoScope

Probability 1,00

TSP

Evidence RBPdetect

Probability 0,91

TSP

Evidence RBPdetect2

Probability 0,94

Protein sequence

MISQFNQPRGSTSIEVNKQSIARNFGVKEDEVVYFTAGIDLSGFKVIYDESTQRAYSLPSGIVSGTTAVSLNEQAILAHSAGSVDLGELAVSREEYVTLPGSFDTGATLNVKNELLTHVAGKYRWEGEFPKTVPAGSTPGSTGGTGTGAWVSVGDASLRSQLSDPDGATKYPDLQIARWRDTFDPRGWNAKGDGVTDDTSALNGVLNAAPVGQKINGNGKTYKVTSLPDISRFVNTRFVYERIPGQPLYYASEEFVQGELFKITDTPYYNAWPQDKAFVYDDVIYCPFMASDRHGVSRLHVSWVRSGDDGQTWTTPEWLTDLHPDYPTVNYHCMSMGVMRNRLFAMIETRTLASNALVTCELWDRPMSRNYHPTGGITKAANQPVAVITIPEHGLFAGDFVNFSNSGVTGVSGNMTVTSVIDRNTFTVTTPNQQAFDQNNSTSRWHMGTSFHESPWRKTSLGLIPMVTEVHSFTAINNDSFMMGYHQGDVAPREVGMLYFPDAFNNPGLYQKRRIPADYEPDAAEPCVKYFDGVLYVLTRGTRSDRLGSSLHRSHDLGMTWESLRFPNNVHHSTLPFAKVGNELIIFATERADNEWEANVPDQRYFTSYPRTFYTRVNLDTWNLDNTQWVNITDQIYQGGIVNSGVGVGSVVVKDSYIYYMFGGEDHLNPWTYGDNSAKDPFKSDGHPSDLYCYKMKIGPDNRVSRDFRYGAVPDRAVPVFFDTNGVRTVPAPMEFTGDLGLGHVTLRASTSNNIRSEMLLEGEYGFIGKSVPTNNPAGQRTIFCGGEGTSSSTGAQITLYGANNTASRRIVYNGAEHLFQTADVKPYNDNAIALGGPSNRFTTAYLGSNPIVTSNGEKKTEPVVFDDAFLDAWGDVHYIMYQWLDAVQLKGNEARIHFGVIAQQIRDVFIAHGLMDENSTDCRYAVLCYDKYPRMTDMVFSHNEIVEHTDEEGNVTTTEEPVFTEVVIHEEGEEWGVRPDGIFFAEAAYQRRKLERIEARLSALEQK

Physico‐chemical properties

protein length:	1008 AA
molecular weight:	112104,37860 Da
isoelectric point:	5,19909
aromaticity:	0,11111
hydropathy:	-0,41587

Domains

Domains [InterPro]

G3DSA:3.30.2020.50
ATT
1–94

G3DSA:3.30.2020.50 G3DSA:2.10.10.80 G3DSA:3.30.750.60 IPR024428 IPR024430 IPR030392

DC_1596
STR
1–254

DC_1596 IPR001724 IPR001724 IPR023366 IPR001724 IPR001724 IPR001724 IPR044914 cd10144

IPR040775
RBD
90–155

IPR040775 IPR024429 G3DSA:2.120.10.10 SSF69349 IPR030392 G3DSA:3.30.2460.10 G3DSA:1.20.5.100

IPR036278
STR
190–704

IPR036278 IPR001724 IPR001724 G3DSA:1.20.5.1240 Coil

IPR024427
ENZ
368–450

IPR024427

IPR001724
Unmapped
442–465

IPR001724

WPH64569.1

1 1008

Architecture

ATT

STR

ATT

STR

CHP

RBD

CHP

RBD

ATT 1-164 | STR 165-183 | ATT 184-256 | STR 257-854 | CHP 855-867 | RBD 868-919 | CHP 920-978 | RBD 979-1008

Legend: ATT STR RBD CBM LEC ENZ CHP LNK TAS TTP UNK Unmapped

Domains [InterPro]

Domain ID	Category	Cluster	Start	End	Layer	Name	Pref Zone	Confidence	Evidence	Support
G3DSA:3.30.2020.50	ATT	G3DSA:3.30.2020.50	1	94	Merged direct domain	G3DSA:3.30.2020.50	N-terminal	Low	Positional only	289 proteins / 289 hits
DC_1596	STR	DC_1596	1	254	Novel HMM	DC_1596	Central	Low	Positional only	84 proteins / 84 hits
IPR040775	RBD	DC_0821	90	155	InterPro cluster	Tail spike TSP1/Gp66, N-terminal domain	Central	High	Text match	1281 proteins / 1285 hits
G3DSA:2.10.10.80	ATT	G3DSA:2.10.10.80	95	164	Merged direct domain	G3DSA:2.10.10.80	N-terminal	Low	Positional only	383 proteins / 383 hits
G3DSA:3.30.750.60	ATT	G3DSA:3.30.750.60	184	256	Merged direct domain	G3DSA:3.30.750.60	N-terminal	Low	Positional only	2 proteins / 2 hits
IPR024429	ENZ	DC_0802	190	256	InterPro cluster	Endosialidase, N-terminal extension domain	N-terminal	High	Text match	84 proteins / 84 hits
IPR036278	STR	IPR036278	190	704	Merged direct domain	Sialidase superfamily	Central	Low	Positional only	56 proteins / 56 hits
IPR024428	ENZ	DC_0114	257	698	InterPro cluster	Endosialidase, beta-propeller domain	Central	High	Text match	92 proteins / 92 hits
IPR001724	Unmapped	-	258	282	InterPro	Glycosyl hydrolase 58	-	-	-	-
G3DSA:2.120.10.10	STR	G3DSA:2.120.10.10	258	698	Merged direct domain	G3DSA:2.120.10.10	Central	Low	Positional only	42 proteins / 42 hits
IPR001724	Unmapped	-	323	351	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR023366	STR	IPR023366	368	454	Merged direct domain	ATP synthase subunit alpha, N-terminal domain-like superfamily	Central	Low	Positional only	44 proteins / 44 hits
IPR024427	ENZ	DC_0382	368	450	InterPro cluster	Endosialidase, beta-barrel domain	Central	High	Text match	86 proteins / 86 hits
IPR001724	Unmapped	-	442	465	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	512	538	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	590	616	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	646	670	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR024430	ENZ	DC_0521	701	854	InterPro cluster	Endosialidase, C-terminal domain	C-terminal	High	Text match	95 proteins / 95 hits
IPR044914	RBD	IPR044914	701	854	Merged direct domain	Endosialidase, C-terminal domain superfamily	C-terminal	Low	Positional only	39 proteins / 39 hits
SSF69349	STR	SSF69349	705	854	Merged direct domain	SSF69349	Central	Low	Positional only	153 proteins / 153 hits
IPR001724	Unmapped	-	747	773	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	779	806	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR030392	CHP	DC_0088	855	1008	InterPro cluster	Intramolecular chaperone auto-processing domain	C-terminal	High	Text match	3502 proteins / 3959 hits
cd10144	CHP	DC_0088	855	994	InterPro cluster	cd10144	C-terminal	High	Text match	3502 proteins / 3959 hits
IPR030392	CHP	DC_0088	859	915	InterPro cluster	Intramolecular chaperone auto-processing domain	C-terminal	High	Text match	3502 proteins / 3959 hits
G3DSA:1.20.5.1240	RBD	G3DSA:1.20.5.1240	868	919	Merged direct domain	G3DSA:1.20.5.1240	C-terminal	Low	Positional only	1 proteins / 1 hits
G3DSA:3.30.2460.10	Unmapped	-	920	978	Gene3D	None	-	-	-	-
G3DSA:1.20.5.100	RBD	G3DSA:1.20.5.100	979	1008	Merged direct domain	G3DSA:1.20.5.100	C-terminal	Low	Positional only	8 proteins / 8 hits
Coil	Unmapped	-	988	1008	Coils	Coil	-	-	-	-

Tail Spike Domain Segmentation

This protein has been segmented into three structural domains: N-terminal, central domain, and C-terminal.

Domain Layout

N-terminal

Central

C-terminal

WPH64569.1

1 1008

Domain	Start	End	Length (AA)	Confidence
N-terminal	1	199	199	0,9952
Central domain	200	521	323	0,8895
C-terminal	522	1008	486	0,6167

Legend: N-terminal Central domain C-terminal

3D Structure with Domain Coloring

The structure is colored according to the domain segmentation: N-terminal (blue), Central (green), C-terminal (pink).

Domain Coloring

N-terminal
1-199

Central
200-521

C-terminal
522-1008

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Escherichia phage YX22 [NCBI]	3093951	Uroviricota > Caudoviricetes > Pantevenvirales > Aglimvirinae >
Host	Escherichia coli APEC IMT5155 [NCBI]	1329907	Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia > Escherichia coli

Coding sequence (CDS)

No CDS data available.

Genome Context

Tertiary structure

PDB ID

96f3a199b07ef9dfab4b8c261b743fca7e449e56e1eef841a39e420bae0cd008

ESMFold

Source ESMFold

Method ESMFold

Resolution 0,6464

Oligomeric State monomer

Download PDB

Model Confidence

Very high
pLDDT > 90

High
90 > pLDDT > 70

Low
70 > pLDDT > 50

Very low
pLDDT < 50

Protein

Domains

Domains [InterPro]

Domains [InterPro]

Tail Spike Domain Segmentation

Tail Spike Domain Segmentation

3D Structure with Domain Coloring

Domain Coloring

Taxonomy

Coding sequence (CDS)

Coding sequence (CDS)

Genome Context

Genome Context

Tertiary structure

Predicted Aligned Error (PAE)

Model Confidence